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EMAGE:5948

Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) ( MGI:87885)
TS17 (10.5 dpc)
in situ hybridisation

Data Images
EMAGE:5948
Fig6A-Chrna1-E10.5 [doi:10.1016/j.ajhg.2007.11.006] Michalk A; Stricker S; Becker J; Rupps R; Pantzar T; Miertus J; Botta G; Naretto VG; Janetzki C; Yaqoob N; Ott CE; Seelow D; Wieczorek D; Fiebig B; Wirth B; Hoopmann M; Walther M; Korber F; Blankenburg M; Mundlos S; Heller R; Hoffmann K, "Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders." Am J Hum Genet 2008; 82: 464-76. [PMID:18252226]

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:5948Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5948_wholemount__moderate.wlz
5948_wholemount__notDetected.wlz
5948_wholemount__strong.wlz
5948_wholemount__possible.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5948_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
trunk somite
detected detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:Chrna1 probeA
Entity Detected:Chrna1, cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) ( MGI:87885)
Notes:The Chrna1 probe used in this study by Michalk et al., 2008 [PMID:18252226] was one of two possible probes, either generated "by RT-PCR from mouse E14.5 whole cDNA" or received "from Bernhard Hermann and Heiner Schrewe (MPI for Molecular Genetics, Berlin)". Neither is of reported sequence.
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:10.5 dpc
Theiler Stage:TS17
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Michalk A; Stricker S; Becker J; Rupps R; Pantzar T; Miertus J; Botta G; Naretto VG; Janetzki C; Yaqoob N; Ott CE; Seelow D; Wieczorek D; Fiebig B; Wirth B; Hoopmann M; Walther M; Korber F; Blankenburg M; Mundlos S; Heller R; Hoffmann K, 2008 [PMID:18252226] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.ajhg.2007.11.006] [ PMID:18252226] Michalk A, Stricker S, Becker J, Rupps R, Pantzar T, Miertus J, Botta G, Naretto VG, Janetzki C, Yaqoob N, Ott CE, Seelow D, Wieczorek D, Fiebig B, Wirth B, Hoopmann M, Walther M, K�rber F, Blankenburg M, Mundlos S, Heller R, Hoffmann K 2008 Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. Am J Hum Genet (82):464-76
Links: Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE