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EMAGE:5960

Fbln1 fibulin 1 ( MGI:95487)
TS17 (10.5 dpc)
in situ reporter

Data Images
EMAGE:5960
Figure 6E. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/j.ydbio.2008.04.029] Dev Biol 319: 336-45, Cooley MA; Kern CB; Fresco VM; Wessels A; Thompson RP; McQuinn TC; Twal WO; Mjaatvedt CH; Drake CJ; Argraves WS, "Fibulin-1 is required for morphogenesis of neural crest-derived structures." Copyright 2008 [PMID:18538758]

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
Note: Ot, otic vesicle; p1, p2 and p3 indicate pharyngeal arches 1, 2 and 3.
Expression Pattern Description
Spatial Annotation:
EMAGE:5960Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
5960_wholemount__moderate.wlz
5960_wholemount__weak.wlz
5960_wholemount__notDetected.wlz
5960_wholemount__strong.wlz
5960_wholemount__possible.wlz
(what is wlz format?)
Download all expression domains: EMAGE:5960_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
neural tube
possible possible
regionalDorsal neural tube region was relatively free of X-gal stained cells.
1st branchial arch
strong strong
2nd branchial arch
strong strong
3rd branchial arch
strong strong
limb
strong strong
trunk somite
strong strong
regionalPronounced expression in anterior and posterior regions of the somites.
heart
detected detected
regionalExpressed in cardiac inflow tract.
ear
detected detected
Pronounced X-gal staining was apparent in populations of cells lateral to the hindbrain, around the otic vesicle.
embryo
detected detected
regionalPronounced X-gal staining was apparent in populations of cells lateral to the hindbrain.
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ reporter
Entity Detected:Fbln1, fibulin 1 ( MGI:95487)
Notes:Fbln1 expression was revealed in this study by Cooley et al., 2008 [PMID:18538758] in embryos heterozygous for a gene trapped allele (mutant ES cell line XST011 obtained from Bay Genomics). The gene trap containing a CD4 and a beta-geo cassette was inserted into exon 14.
Labelled with:LacZ
Specimen
Organism:mouse
Strain:C57BL/6
Age:10.5 dpc
Theiler Stage:TS17
Mutations:Fbln1Gt(XST011)Byg/Fbln1+
Preparation:wholemount
Procedures
Fixation:4% paraformaldehyde
General Information
Authors:Cooley MA; Kern CB; Fresco VM; Wessels A; Thompson RP; McQuinn TC; Twal WO; Mjaatvedt CH; Drake CJ; Argraves WS, 2008 [PMID:18538758] . Indexed and spatially mapped by EMAGE.
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/j.ydbio.2008.04.029] [ PMID:18538758] Cooley MA, Kern CB, Fresco VM, Wessels A, Thompson RP, McQuinn TC, Twal WO, Mjaatvedt CH, Drake CJ, Argraves WS 2008 Fibulin-1 is required for morphogenesis of neural crest-derived structures. Dev Biol (319):336-45
Links:MGI:3802971 allele description
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceEMAGE