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EMAGE:694

Nrg1 neuregulin 1 ( MGI:96083)
TS15 (9.5 dpc)
in situ hybridisation

Data Images
EMAGE:694
Figure 3C of Meyer et al., 1997 [PMID:9342050] Copyright: This image is from Development and is displayed with the permission of The Company of Biologists Ltd. who owns the copyright.

Expression pattern clarity: two stars
Find spatially similar wholemount expression patterns: Find spatially similar wholemount patterns
Notes:
The authors state that this gene is not detected at this stage and that expression first appears at E10 in the cranial ganglia, dorsal root ganglia and in developing motoneurons located in the ventral column of the spinal cord.
Expression Pattern Description
Spatial Annotation:
EMAGE:694Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
wholemount mapping

Download individual expression domains:
694_wholemount_possible_3D_1.wlz
694_wholemount_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:694_all_domains.zip
Find spatially similar wholemount expression patterns:  EMAGE spatially similar wholemount patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
glossopharyngeal ix preganglion
not detected not detected
Lack of expression in the geniculate ganglion.
cranial preganglion
not detected not detected
vagus x preganglion
not detected not detected
trigeminal v preganglion
not detected not detected
future spinal cord
not detected not detected
Lack of expression in the ventral column of the spinal cord.
dorsal root ganglion
not detected not detected
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:2155221
Entity Detected:Nrg1, neuregulin 1 ( MGI:96083)
Notes:The neuregulin (Nrg1) type III probe used in this study by Meyer et al., 1997 [PMID:9342050] is described as "a mouse cDNA fragment", "corresponding to sequences that encode segment a (nucleotides 450-1192 in the reported human SMDF sequence, Ho et al., 1995 [PMID:7782315] )."
Chemistry:RNA
Strand:antisense
Label:digoxigenin
Specimen
Organism:mouse
Age:9.5 dpc
Theiler Stage:TS15
Mutations:none (wild-type)
Preparation:wholemount
Procedures
General Information
Authors:Meyer et al., 1997 [PMID:9342050] Indexed by GXD, Spatially Mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ PMID:9342050] Meyer D, Yamaai T, Garratt A, Riethmacher-Sonnenberg E, Kane D, Theill LE, Birchmeier C 1997 Isoform-specific expression and function of neuregulin. Development (124):3575-86
 [ doi:10.1074/jbc.270.24.14523] [ PMID:7782315] Ho WH, Armanini MP, Nuijens A, Phillips HS, Osheroff PL 1995 Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons. J Biol Chem (270):14523-32
Links:MGI:2155235 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI