EMAGE mouse gene expression spatial database

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EMAGE:717

Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) ( MGI:97357)
TS20 (12.5 dpc)
in situ hybridisation

Data Images


Figs 9A,B Moens et al, 1993 [PMID:8287798] . Copyright: These images are from Development and are displayed with the permission of the Company of Biologists Ltd who own the copyrights.	Figs 9F,G Moens et al, 1993 [PMID:8287798] . Copyright: These images are from Development and are displayed with the permission of the Company of Biologists Ltd who own the copyrights.

Expression pattern clarity:
Find spatially similar expression patterns:

Notes:

Image annotations: A, atrium; C, compact layer; E, endocardial cushion; Ep, epicardium; LV, left ventricle; T, trabeculae Figs 9f/g show a higher magnification view fo the data in Figs 9a/b.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

3D mapping

3D context movie

View mapped 3D expression image

Download individual expression domains:

717_voxel_strong_3D_1.wlz

717_voxel_notDetected_3D_1.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:717_all_domains.zip

Find spatially similar expression patterns:

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

heart

detected

regional

N-myc was present in the compact layer of the heart

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:1276340
Entity Detected:	Mycn, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) ( MGI:97357)
Sequence:	sense strand is shown >MGI:1276340 GGCGAGGCAGCAGCAGTTGCTAAAGAAGATCGAACACGCTCGGACTTGCTAAACGTTTCCCACACGGACA GTCACTGCCACTTTGCACATTTTGATTTTTTTTTTTTTAAACAAACATTGTGTTGACATTAAGAATGTTG GTTTACTTTCAAATTGGTCCCCTGTCGAGTCTGGATCTGGGTAGGGGGCAGGACACGGGGTTCTGCCATG ACCTTGGAAAAAAAACTGACTCACGGGATGCTGGGTGGCTTGTTTTCCTCCTCCATATCACCTGGTGACA GCCGTGGAAGTTCGGGACACTAAGGAGCTTCAGGAGGCTGTGAAGTCACCTTGTTCCGGTCCAAGATTCC AAACAGAGTCATTCCTTCTTTTTACAATGGTGCTTAAGTTCCAGCAAATGCCACAGAAGGGGGGGTTGCC ATTTGATGCCCTTGGGAACACTTGTGAAATACCATTGATACACCCGCCTTTGTATACGTCTGGGGTAATG AGAGGTGGCTCTTGCGGCCAGTATTAGACTGGAGTTCACACCTAAGT
	nt 6258 - nt 6794 of M12731.1
Notes:	The Nmyc1 (N-myc) probe used in this study by Moens et al, 1993 [PMID:8287798] is described as "a 541 bp Pst1-Sca1 fragment of the N-myc genomic clone N7.7 (DePinho et al., 1986 [PMID:3513190] ), including largely 3'-untranslated sequence". This region is denoted here with reference to the accompanying GenBank entry from DePinho et al, 1986.
Chemistry:	RNA
Strand:	antisense
Label:	S35

Specimen

Organism:	mouse
Age:	12.5 dpc
Theiler Stage:	TS20
Mutations:	none (wild-type)
Preparation:	section

Procedures

Fixation:	10% formalin
Embedding:	paraffin
Staining procedure:	autoradiography

General Information

Authors:	Moens et al, 1993 [PMID:8287798] Indexed by GXD, Spatially mapped by EMAGE
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ PMID:8287798] Moens CB, Stanton BR, Parada LF, Rossant J 1993 Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development (119):485-99
	[ doi:10.1073/pnas.83.6.1827] [ PMID:3513190] DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW 1986 Structure and expression of the murine N-myc gene. Proc Natl Acad Sci U S A (83):1827-31
Links:	MGI:1276352 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source