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EMAGE:3774

Eda ectodysplasin-A ( MGI:1195272)
TS16 (10.0 dpc)
in situ hybridisation

Data Images
EMAGE:3774
Fig 1I.Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(99)00180-X] Mech Dev 88: 133-46, Mikkola ML; Pispa J; Pekkanen M; Paulin L; Nieminen P; Kere J; Thesleff I, Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Copyright 1999

Expression pattern clarity: three stars
Find spatially similar expression patterns: Find spatially similar patterns
Expression Pattern Description
Spatial Annotation:
EMAGE:3774EMAGE:3774Annotation colour key:  
strong strong      
gene expression moderate moderate    
gene expression weak weak        
gene expression possible possible    
gene expression not detected not detected
3D mappingspatial mapping

View mapped 3D expression image EMAGE genex expression entry
Download individual expression domains:
3774_voxel_strong_3D_1.wlz
3774_voxel_notDetected_3D_1.wlz
(what is wlz format?)
Download all expression domains: EMAGE:3774_all_domains.zip
Find spatially similar expression patterns: EMAGE spatially similar patterns
Morphological match to the template: two stars
Text Annotation:
StructureLevelPatternNotes
rathke's pouch
strong strong
Annotation Validation: EMAGE Editor
Detection Reagent
Type:in situ hybridisation probe
Identifier:MGI:2388501
Entity Detected:Eda, ectodysplasin-A ( MGI:1195272)
Notes:The Eda (Tabby) probe used in this study by Mikkola et al, 1999 [PMID:10534613] was described as a "Tabby-A specific probe", that "was derived from Tabby-A3 clone and corresponds to nucleotides 2371-3164". This probe "recognizes all Tabby-A forms". Editors Note: In Section 2.1 of this paper the authors state that the Ta-A3 (or E2) clone was 3.1 kb long, without a polyA tail and the open reading frame encodes a protein 386 aa in length. It has the EMBL database accession number AJ243658. Cross-checking of this information shows that AJ243658.1 is 3096nt in length. Ambiguous information - probe length unknown.
Chemistry:RNA
Strand:antisense
Label:P33
Specimen
Organism:mouse
Strain:involves: CBA-T6T6 * NMRI
Age:10.0 dpc
Theiler Stage:TS16
Mutations:none (wild-type)
Preparation:section
Procedures
Embedding:paraffin
Staining procedure:autoradiography
General Information
Authors:Mikkola ML; Pispa J; Pekkanen M; Paulin L; Nieminen P; Kere J; Thesleff I, 1999 [PMID:10534613] . Indexed by GXD, Spatially mapped by EMAGE
Submitted by:EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:non-screen
References:[ doi:10.1016/S0925-4773(99)00180-X] [ PMID:10534613] Mikkola ML, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, Thesleff I 1999 Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev (88):133-46
 [ doi:10.1073/pnas.94.24.13069] [ PMID:9371801] Srivastava AK, Pispa J, Hartung AJ, Du Y, Ezer S, Jenks T, Shimada T, Pekkanen M, Mikkola ML, Ko MS, Thesleff I, Kere J, Schlessinger D 1997 The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A (94):13069-74
Links:MGI:2389026 same experiment
  Ensembl same gene
  Allen Brain Atlas same gene
  BioGPS same gene
  International Mouse Knockout Project Status same gene
  GEISHA Chicken ISH Database same gene
  EMBL-EBI Gene Expression Atlas same gene
  BrainStars same gene
  ViBrism same gene
Data SourceMGI