EMAGE mouse gene expression spatial database

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EMAGE:4164

Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) ( MGI:1354756)
TS18 (11 dpc)
in situ hybridisation

Data Images


Figure 3C. Copyright: Reprinted with permission from Elsevier from [doi:10.1016/S0925-4773(99)00248-8] Mech Dev 90: 181-93, Kolle G; Georgas K; Holmes GP; Little MH; Yamada T, CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Copyright 2000.

Expression pattern clarity:
Find spatially similar wholemount expression patterns:

Notes:

Note: ey, eye; ot, otic vesicle; so, somites. Scale bar: 500 microns.

Expression Pattern Description

Spatial Annotation:

Annotation colour key:

	strong
	moderate
	weak
	possible
	not detected

wholemount mapping

Download individual expression domains:

4164_wholemount_strong_3D_1.wlz

4164_wholemount_moderate_3D_1.wlz

4164_wholemount_possible_3D_1.wlz

(what is wlz format?)

Download all expression domains:

EMAGE:4164_all_domains.zip

Find spatially similar wholemount expression patterns:

EMAGE spatially similar wholemount patterns

Morphological match to the template:

Text Annotation:

Structure

Level

Pattern

Notes

trunk somite

detected

Expression is in more caudal somites.

lens vesicle

detected

neural tube

detected

regional

Expression is in the ventral aspect.

1st branchial arch mandibular component

detected

regional

Expression is in a portion of the developing tooth primordia.

1st branchial arch maxillary component

detected

regional

Expression is in a portion of the developing tooth primordia.

otocyst

detected

regional

Expression is in a portion of the otic vesicle.

Annotation Validation:

EMAGE Editor

Detection Reagent

Type:	in situ hybridisation probe
Identifier:	MGI:3033359
Entity Detected:	Crim1, cysteine rich transmembrane BMP regulator 1 (chordin like) ( MGI:1354756)
Sequence:	sense strand is shown >MGI:3033359 ATGTGCACAACTGTGAACTCTGTCAGTGCCGCCCACGGCCCAAGAAGTGCAGACCAACAATGTGCGACAA GTTTTGTCCGCTTGGATTCCTGAAGAATAAGCATGGCTGTGACATCTGTCGGTGTAAGAAATGTCCAGAG CTGCCATGCAGCAAGATCTGCCCCTTGGGCTTCCAGCAGGACAGTCATGGCTGTCTTATCTGCAAGTGCC GAGAGGTCCCTCCTTCAGCCGGGCCACCTGTCCTGTCAGGCACATGTCTGTCCATGGATGGCCATCATCA TAAGAACGAGGAGAGCTGGCATGATGGTTGCCGGGAATGCTACTGTCACAACGGAAAGGAAATGTGCGCT CTCATCACCTGTCCCGTGCCTGCCTGCGGCAACCCCACCATTCGTTCCGGACAGTGCTGCCCGTCTTGCA CAGATGACTTTGTAGTGCAGAAGCCGGAGCTCAGCACCCCTTCTATTTGCCACGCCCCCGGAGGAGAGTA CTTTGTGGAAGGGGAAACTTGGAACATTGACTCCTGTACACAGTGCACCTGTCACAGTGGTCGAGTGCTG TGTGAGACGGAGGTGTGCCCACCATTGCTCTGCCAGAACCCCTCCCGCACCCAGGACTCCTGCTGCCCAC AGTGTACAGATGACCCTCCTCAGCCTTCCACATCCCATAATGAGAGCGTGCCTAGCTACTGCAGGAATGA TGAAGGAGATATCTTCCTGGCGGCTGAGTCCTGGAAGCCCGACGCCTGCACCAGCTGCGTGTGCGTGGAT AGCGCAATTAGCTGCTACTCTGAGTCTTGCCCTTCCGTGGCCTGTGAAAGACCTGTTTTGAGGAAAGGCC AGTGTTGCCCCTACTGCTTAGAAGACACAATTCCAAAGAAAGTGGTGTGTCACTTCAGTGGGAAGACCTA TGCTGACGAGGAACGGTGGGATATTGACAGCTGCACRCACTGCTACTGCCTGCAAGGCCAGACCCTCTGC TCGACCGTCAGCTGCCCACCGTTACCCTGTGCCGAGCCCATCAAGGTGGAAGGGAGTTGCTGCCCAATGT GCCCAGAAATGTATGTGCCAGAGCCAACCAATGTACCCATTGAGAAGAAAAATCATCGTGGCGAGATTGA CCTGGAGGTCCCCATGTGGCCCACCCCAAGTGAAAATGACATCATCCATCTCCCTAGAGATATGGGTCAC CTCCAGGTAGATTACAGAGATAATAACAGGCTGCATCCAGGCGAAGACTCATCACTGGACTCCATTGTCT CCGTTGTGGTTCCCATAATAATATGCCTGTCCATCATCATAGCTTTCCTGCTCATCAACCAGAAGAAGCA GTGGGTACCACTGCTGTGCTGGTACCGGACACCAACCAAGCCTTCTTCCTTGAATAATCAGCTGGTATCT GTGGACTGCAAGAAAGGCACTCGAGTCCAGGTGGATGGTCCCCAGAGAATGCTAAGAATTGCCGAACCAG ATGCTCGATTCAGTGGCTTCTACAGCATGCAGAAACAGAACCATCTACAGGCAGACAACTTCTACCAAAC GGTGTGAACACGGGCAGCAGCGCCGATGAGGTCCCGAAAGACGGAGAAAGACGAAAATCTGCTCTTTAAA GTAAACTAGGATTTGCGCACTTGCTTAGTGTCTTGTGTCAGATTGCGACTTGGTGTCCAGCGCTAGGGGC TGGACTGGGATGGGCTCTGTCTACAGCACTGTGCAGAACAAGCATTCCCACTTGGCCTCAAGATAACTGA CCACATGTTTTCATAGAACCAAAGTTTTAAAACTTGCTAAAGTATATTTGCTTGTAAGATAGCTGTAGAG ACATTTGGGGGAGGGGAG
	nt 1541 - nt 3378 of AF168680.1
Notes:	The Crim1 probe used in this study by Kolle et al., 2000 [PMID:10642437] was transcribed from a "Crim-1 cDNA clone, nucleotides 1541-3378". Editors note: the authors are presumed to have related these co-ordinates to the mouse cDNA Crim1 sequence they deposited in GenBank (AF168680.1)
Chemistry:	RNA
Strand:	antisense
Label:	digoxigenin

Specimen

Organism:	mouse
Strain:	either: CD-1 or Swiss
Age:	11 dpc
Theiler Stage:	TS18
Mutations:	none (wild-type)
Preparation:	wholemount

Procedures

Fixation:

4% paraformaldehyde

General Information

Authors:	Kolle G; Georgas K; Holmes GP; Little MH; Yamada T, 2000 [PMID:10642437] . Indexed by GXD, Spatially mapped by EMAGE.
Submitted by:	EMAGE EDITOR, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK EH4 2XU
Experiment type:	non-screen
References:	[ doi:10.1016/S0925-4773(99)00248-8] [ PMID:10642437] Kolle G, Georgas K, Holmes GP, Little MH, Yamada T 2000 CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev (90):181-93
Links:	MGI:3033361 same experiment
	Ensembl same gene
	Allen Brain Atlas same gene
	BioGPS same gene
	International Mouse Knockout Project Status same gene
	GEISHA Chicken ISH Database same gene
	EMBL-EBI Gene Expression Atlas same gene
	BrainStars same gene
	ViBrism same gene
Data Source